1. Macdonald, L.;  Taylor, G. C.;  Brisbane, J. M.;  Christodoulou, E.;  Scott, L.;  von Kriegsheim, A.;  Rossant, J.;  Gu, B.; Wood, A. J., Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons. Elife 2022, 11.

This paper describes the proof of concept study demonstrating using the Auxin Inducible Degradation system for manipulating endogenous proteins in live mice.

2. Gu, B.;  Bradshaw, B.;  Zhu, M.;  Sun, Y.;  Hopyan, S.; Rossant, J., Live imaging YAP signalling in mouse embryo development. Open Biology 2022, 12 (1), 210335.

This paper describes the first knock-in reporter model for imaging dynamic Yap signaling in mice.


1. Gu, B.;  Posfai, E.; Rossant, J., Efficient generation of targeted large insertions by microinjection into two-cell-stage mouse embryos. Nat Biotechnol 2018, 36 (7), 632-637.

This paper describes the 2C-HR-CRISPR technology for efficiently generating large fragment knock-in mouse models.

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